Dear Sir or Madam, Dear Partner,

With the collaboration of our current commercial partner, Conception Technologies, Cryo Bio System has built and significantly developed its presence in the USA over the past years. We certainly appreciate the trust you have demonstrated by routinely using our products in your center.

We would like to inform you of the organizational changes that will take effect in the near future: Beginning April 1st 2009, Irvine Scientific will be given exclusive distributorship of Cryo Bio System products for the Assisted Reproduction market segment in the USA. From then on, please contact Irvine Scientific at 1-800-437-5706 or tmrequest@irvinesci.com to order Cryo Bio System items, or for any request of information on the products.

Please, be assured that we are working to ease the transition so that it will be of no consequence in your daily activity. We thank you again for your understanding and continuous patronage. Please, don’t hesitate to contact us should you have any question (contact@cryobiosystem-imv.com).

Sincerely,

Cryo Bio System

NB/ Our High Security Vitrification (HSV) kits are currently unavailable on the US market awaiting 510(k) FDA approval.